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Research Article

Transcriptional Profiling of Soft-rot Resistant Transgenic Chinese Cabbage (Brassica rapa L.) Constitutively Overexpressing a Human Cathelicidin Antimicrobial Peptide (hCAP18/LL-37)

Yu-Jin Jung1,2,*
Plant Breeding and Biotechnology 2013;1(1):80-90.
Published online: March 31, 2013

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*Corresponding author Yu-Jin Jung, yuyu1216@hknu.ac.kr, Tel: +82-31-678-4642, Fax: +82-31-670-5109
• Received: March 18, 2013   • Revised: March 22, 2013   • Accepted: March 22, 2013

Copyright © 2013 The Korean Society of Breeding Science

This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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  • Enhanced resistance to bacterial pathogen in transgenic tomato plants expressing cathelicidin antimicrobial peptide
    Yu-Jin Jung
    Biotechnology and Bioprocess Engineering.2013; 18(3): 615.     CrossRef

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Transcriptional Profiling of Soft-rot Resistant Transgenic Chinese Cabbage (Brassica rapa L.) Constitutively Overexpressing a Human Cathelicidin Antimicrobial Peptide (hCAP18/LL-37)
Plant Breed. Biotech.. 2013;1(1):80-90.   Published online March 31, 2013
DOI: https://doi.org/10.9787/PBB.2013.1.1.080
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Transcriptional Profiling of Soft-rot Resistant Transgenic Chinese Cabbage (Brassica rapa L.) Constitutively Overexpressing a Human Cathelicidin Antimicrobial Peptide (hCAP18/LL-37)
Plant Breed. Biotech.. 2013;1(1):80-90.   Published online March 31, 2013
DOI: https://doi.org/10.9787/PBB.2013.1.1.080
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Transcriptional Profiling of Soft-rot Resistant Transgenic Chinese Cabbage (Brassica rapa L.) Constitutively Overexpressing a Human Cathelicidin Antimicrobial Peptide (hCAP18/LL-37)
Image Image Image Image
Fig. 1 Hierarchical clustering among the genes highly expressed antimicrobial peptide LL-37 transgenic and wild type plants in Brassica rapa using KBGP-24K chip. Four representative patterns (A~D) displayed similar expression patterns, respectively. Expression values higher and lower than those of the control are shown in red and green, respectively.
Fig. 2 Functional categorization of upregulated and downregulated differentially expressed genes. 910 significantly upregulated and 505 significantly downregulated DEGs were categorized to biological process, molecular function, and cellular component based on GO annotation, and the represented number of each column was marked in the figure.
Fig. 3 Validation of microarray data. Each of twenty genes of up- and down-regulated genes showing differential expression in our microarray experiments was selected and their relative expression determined using qRT-PCR.
Fig. 4 Disease response and RT-PCR analysis in transgenic lines (TG23, TG34) and wild type. (A), (B) Enhancing bacterial disease resistance in transgenic plants to 3 days leaf after infection. (B) Semi-quntitative RT-PCR analysis of expression levels of candidate genes identified by microarray analysis in LL-37 transgenic and wild type control inoculated with 108 CFU/ml of P. carotovorum ssp. carotovorum after 48 hours.

Fig. 1

Fig. 2

Fig. 3

Fig. 4

Transcriptional Profiling of Soft-rot Resistant Transgenic Chinese Cabbage (Brassica rapa L.) Constitutively Overexpressing a Human Cathelicidin Antimicrobial Peptide (hCAP18/LL-37)

Significantly twenty up-regulated genes among genes in the LL-37 transgenic plants and wild type using KBGP-24K oligo chip.

Clone number Fold over expression Gene ID Description
28869 48.87 EAK95476 Potential purine-cytosine permease
26645 31.37 AT1G62940 Similar to ataxia/oculomotor apraxia protein 2
22041 29.07 AAL91065 NADH dehydrogenase subunit 6
00544 21.29 AT1G12520 Cu/Zn superoxide dismutase copper chaperone like protein
00089 20.49 AT1G20693 Chromatin-associated proteins
24612 18.98 AAG51989 Glyoxalase II, putative
02138 18.76 AT1G20760 Calcium-binding EF hand family protein
01218 17.32 AT4G25780 PR-1 protein from Medicago truncatula
15181 17.29 AT1G22080 Unknown protein
19064 13.74 AT4G22880 Anthocyanidin synthase
19451 13.20 AT1G64160 Disease resistance-responsive family protein
11475 12.89 AT5G44420 Plant defensin protein family
00303 12.69 AT4G25100 Superoxide dismutase
01138 6.72 AT1G27310 Similar to nuclear transport factor 2
07649 4.68 AT1G06830 Glutaredoxin, putative
25621 4.32 AT2G21100 Disease resistance-responsive protein
04541 4.25 AT5G38195 Protease inhibitor contains lipid transfer protein (LTP)
19333 3.79 AT4G19880 Glutathione S-transferase-related
29028 3.71 AT1G28520 Putative myosin heavy chain
15849 3.39 AT5G57350 ATPase

Significantly twenty down-regulated genes among genes in the LL-37 transgenic plants and wild type using KBGP-24K oligo chip.

Clone number Fold down expression Gene ID Description
19596 0.39 AT4G29190 Putative CCCH-type zinc finger protein
03882 0.38 AT4G38960 RNA-directed DNA polymerase-like protein
14945 0.37 AT5G18110 Novel cap-binding protein nCBP
07928 0.37 AT4G18170 WRKY family transcription factor, similar to DNA-binding protein 2
16572 0.36 AT5G62360 Unknown protein
21724 0.36 AT5G06860 Polygalacturonase inhibiting protein 1
02287 0.35 AT5G05340 PERP7_BRARA Peroxidase P7 (TP7)
02119 0.35 AT3G55770 Putative transcription factor L2
00753 0.34 AT5G06730 Putative peroxidase
19993 0.33 AT4G19840 Lectin like protein
15333 0.33 AT3G53140 Caffeic acid O-methyltransferase-like protein
14083 0.32 AT3G18490 Putative chloroplast nucleoid DNA-binding protein
23389 0.32 CAH70024 Trichohyalin
04373 0.28 AT4G02980 Susceptible endoplasmic reticulum auxin-binding protein 2
14555 0.19 AT2G02930 Glutathione S-transferase 6
02692 0.17 AT5G02020 Putative protein
06607 0.15 AT1G56600 Galactinol synthase-like protein
24949 0.14 XP_416059 Similar to SF21 protein
00671 0.09 AT2G30490 Cinnamate-4-hydroxylase
02751 0.06 AT1G80130 Unknown protein
Table 1 Significantly twenty up-regulated genes among genes in the LL-37 transgenic plants and wild type using KBGP-24K oligo chip.
Table 2 Significantly twenty down-regulated genes among genes in the LL-37 transgenic plants and wild type using KBGP-24K oligo chip.

Table 1

Table 2

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